Beijing Sinovac to produce EV71 vaccine against HFMD

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Recently, Beijing-based Sinovac Biotech announced that the China Food and Drug Administration (FDA) has issued the Good Manufacturing Practices certificate for the company’s Enterovirus 71 vaccine. The vaccine is made from inactivated enterovirus 71.

Yang Guang, Sinovac investor relations director said that preclinical and clinical studies showed that the EV71 vaccine is effective and safe. This vaccine targets children that are aged 6 months to 3 years old. 

The company intends to start the manufacture of the vaccine at the end of January this year. 

Source: http://www.biopharma-reporter.com/Markets-Regulations/Beijing-Sinovac-to-produce-vaccine-against-hand-foot-and-mouth-disease (27 January 2016)

 

Two-year efficacy and immunogenicity of Sinovac Enterovirus 71 vaccine against HFMD in children

This research was done to evaluate the efficacy and immunogenicity of Sinovac Enterovirus 71 vaccine for up to two years. 

10,077 participants were randomised to receive EV71 vaccine or placebo in a 1:1 ratio, and followed for 14 months. Extended follow-up was done for 12 months and the primary endpoint pf the study was EV71-associated HFMD. 

The EV71 vaccine showed an efficacy of 95.1% against EV71-associated HFMD in the extended follow-up, and showed an overall efficacy of 94.7% for two years. The vaccine induced a high level of neutralising antibodies in the patients, with no serious side effects observed. 

Therefore, it shows that the vaccine is able to provide a high protection against EV71-associated HFMD for up to 2 years. 

Source: http://www.ncbi.nlm.nih.gov/pubmed/26460695

More HFMD cases recently, but ‘no cause for alarm’

More HFMD cases are being reported in Singapore this year as compared to the same period last year, according to weekly figures published by the Ministry of Health. 

There were 568 HFMD cases from 6 December to 12 December 2015, compared with 302 cases during the same period in 2014. For this period from 2010 to 2014, the median number for HFMD cases was also 302. 

Source: http://www.channelnewsasia.com/news/singapore/more-hfmd-cases-recently/2371202.html (23 December 2015)

 

 

China FDA Approves EV71 Vaccine, HFMD in Asia

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The China Food and Drug Administration (FDA) announced that an enterovirus 71 inactivated vaccine (human diploid cell) is approved. This vaccine is designed by the Institute of Medical Biology, Chinese Academy of Medical Sciences. 

The vaccine for children effectively reduce the cases of hand, foot and mouth disease (HFMD), in particular reducing the severe and fatal cases of the disease. It has shown a 97.3% protection rate against EV71 in clinical trials.

Source: http://outbreaknewstoday.com/china-fda-approves-ev71-vaccine-hfmd-in-asia-37311/ (7 December 2015)

Severe Pediatric Enterovirus 71 Infection Investigated in Hong Kong

Hong Kong health officials are investigating on a severe pediatric enterovirus 71 and an outbreak of hand, foot and mouth disease (HFMD) at a secondary school in Eastern District. 

The patient is a 13 year old boy with good past health. He had symptoms of HFMD such as fever, sore throat, headache, stiff neck and rash since 7 November 2015. Apart from the patient, 12 other students aged 13 to 14, were infected with HFMD. 

As of 7 November 2015, there were 736 HFMD cases reported in 2015. This was an increase from 327 cases reported in the same period in 2014.

Source: http://outbreaknewstoday.com/severe-pediatric-enterovirus-71-infection-investigated-in-hong-kong-80427/ (25 November 2015)

Hong Kong Investigate HFMD in Kowloon Tong School

The Centre for Health Protection (CHP) of the Department of Health is investigating an outbreak of hand, foot and mouth disease (HFMD) at a primary school, Kowloon Tong School.

21 students, 16 boys and 5 girls, aged 6 to 10 years old, were infected with HFMD. They have developed fever, oral ulcers, rash on their hands and feet, since 23 October 2015. All are now in stable condition. 

Officers of CHP have advised the school staff on necessary infection control and preventive measures, as well as the public to maintain strict personal and environmental hygiene. 

Source: http://outbreaknewstoday.com/hong-kong-investigate-hfmd-in-kowloon-tong-school-hospital-admission-double-compared-to-2014/ (13 November 2015)

Chiang Rai Parents told to Safeguard their children against HFMD

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Chiang Rai – The Department of Disease Control (DDC) reported more than 30,000 children in Thailand that have been diagnosed with Hand Foot & Mouth Disease (HFMD) this year during the period between the rainy season and winter. Out of the 30,000 cases, 3 were fatal. 

Due to this huge number and rise in HFMD cases, DDC urged parents and childcare centers to safeguard their children against infection by ensuring hygiene and seeking medical attention if HFMD symptoms are present. 

Source: http://www.chiangraitimes.com/chiang-rai-parents-told-to-safeguard-their-children-against-hfmd.html (6 November 2015)

Several cases of Hand Foot and Mouth Disease at Livonia High School

There were a few Hand, Foot & Mouth Disease (HFMD) cases reported at Livonia County high school. Parents in Livonia were informed about the situation through a letter the school had sent to them.

In a video, News10NBC spoke with a girl who had been infected with HFMD, as she shared her experience being infected with the disease. 

Click here to watch the video. 

Source: http://www.whec.com/article/stories/s3945188.shtml (26 October 2015)